The human body has a set of bacteria in various parts of the body, like in the mouth, deep in the skin layers, etc. Similar is the gut microbiota, which consists of millions of both good and bad bacteria. Those microorganisms assist the body to process food and convert it into energy. But a new study claims some bacteria in the gut might fuel the risk of developing bowel cancer. Even more, it relates human health to the microbes present in the gut. As mentioned above, the gut microbiome is a cluster of bacteria, fungi, viruses within our stomach. The study focuses on these bacteria and holds few microbiota structures liable for various conditions ranging from anxiety to fatness.
A team of researchers has presented their findings at the NCRI (National Cancer Research Institute) conference, Glasgow. The study asserts the existence of a causal relationship between a particular type of gut bacteria and an increased risk of bowel cancer. Kaitlin Wade from the University of Bristol has worked on the project and is a co-author of the study. He said many researchers in mice and humans had revealed a link between the gut’s microbial community and bowel cancer. Kaitlin noted, but very few trials have offered compelling evidence for cause and effect. He said it is complicated to notice whether elements of the gut microbiome can lead to bowel cancer. Besides, it is challenging to analyze, whether the disease itself results in changes in the gut microbiome. Eventually, it is difficult to know whether the relationship is because of some other factors which make changes in both.
The latest study has estimated various datasets seeking to focus on specific genetic variations linked with bowel cancer. The researchers have used Mendelian randomization, a type of statistical analysis, to show causal links in big data. Even more, the study has unveiled a biological evolution linked to a particular type of bacteria from the Bacteroidales group. As per scientists, the cluster seems to boost up to 15% risk of developing bowel cancer in a person. Although, it is a first-ever study to use Mendelian randomization for revealing a probable causing association.